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Testing & Diagnosing: Landmark Study Identifies Neurons Especially Vulnerable to Alzheimer’s Disease!!

Alzheimer's Disease

Alzheimer’s Disease – It’s a calamitous state that is invincible and incurable right now. The foremost cause is reported to be the loss of neurons and brain cells in the brain. This act gives a way to memory problems and a few other cognitive functions. Researchers recognize which neurons show increased vulnerability to Alzheimer’s disease based on their location inside the brain and how they look like.

Recent Researches Report:

Yet, they have no idea so far, what genes or proteins those neurons exhibit. Identifying these factors is essential for recognizing the changes in certain cells that arise when the disease is present. Recent research has revealed that neurons showing specific proteins act more vulnerable to degeneration.  To conduct their study to understand more in-depth, scientists conducted a post-mortem brain analysis on people who had this disease.

Alzheimer's disease

To figure out how far the disease had advanced, they started by looking for build-ups of the protein tau in various parts of the brain. Tau proteins aggregate in cells, which causes the cells to die for people with Alzheimer’s disease. Tau expands adversely in different brain areas, which is why a few areas show a greater degree of degeneration.

After identifying the disease progression, the researchers directed their attention to 2 specific brain sections: the superior frontal gyrus & the entorhinal cortex. The entorhinal cortex is linked to memory, while the other operates, associated with self-awareness. Tau grows in the entorhinal cortex in the initial stages of Alzheimer’s disease. But not until later on in the superior frontal gyrus. Scientists lookup for differences in the same cell types, just by glancing at two areas with different cell loss in multiple stages. It also might allow them to uncover what makes them weak, and when they become vulnerable.

Alzheimer's disease

What observations are analyzed?

The researchers observed that a specific type of neuron named excitatory neurons was the most vulnerable of the cells analyzed. They discovered that certain neurons exhibited a 50% decline in their numbers during the early steps of Alzheimer’s disease. As this study centered solely on brain samples taken from males with a specific Alzheimer’s disease-related gene, it is complicated stimulating to know whether these conclusions will also be alike in women or with different genetic backgrounds.

Nevertheless, this study provides a better understanding of the cells which are exposed to Alzheimer’s disease. Future studies focusing on RORB in neurons also its functions yield exciting results, and hopefully interesting therapies.